NEW VARIANT OF PRDM16 GENE NUCLEOTIDE SEQUENCE IN A FAMILY WITH VARIOUS PHENOTYPIC MANIFESTATIONS OF THE NON-COMPACTED MYOCARDIUM

New variant of PRDM16 gene nucleotide sequence in a family with various phenotypic manifestations of the non-compacted myocardium

The article presents the examination of three generations of a family with diagnosed left ventricular noncompaction (LVNC) and various phenotypic manifestations of the disease (isolated, hypertrophic and dilated type of LVNC).As a result of a molecular genetics dc wire harness tests, a previously undescribed single nucleotide deletion in the PRDM16

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Involvement of GABAB receptor in the antihypersensitive effect in anterior cingulate cortex of partial sciatic nerve ligation model

The role of the GABAB receptor in the anterior cingulate cortex (ACC) of neuropathic pain is unclear.Injection of a GABAB receptor antagonist CGP35348 into the ACC induced mechanical hypersensitivity in normal rats.Activation of the GABAB receptor injected by a GABAB receptor SORE THROAT SPRAY agonist baclofen into the ACC attenuated mechanical hyp

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